Gentle, high-throughput biomass clarification; preserve cell viability, maximise recovery, and scale your bioprocess with confidence.
- In modern biomanufacturing; including enzymes, vaccines, microbial proteins, and pharmaceutical intermediates; separating bacterial or fungal biomass from fermentation broth is a key step in achieving purity and consistency.
- Conventional filtration or sedimentation methods often lead to yield loss, product shear damage, or fouling, driving up maintenance and reducing throughput.
- Producers need scalable, hygienic separation systems that handle high cell densities with minimal shear, maintaining product quality and process reproducibility.
Our Solution:
- 4B Automation & 4B Systems supplies and integrates Alfa Laval centrifugal separator systems purpose-engineered for microbial and biotech applications.
- Alfa Laval MB series, Bactofuge® and BTUX units; are designed for high cell-density streams, providing gentle acceleration, continuous solids discharge, and hermetic, low-shear operation.
- With 4B Automation & 4B Systems’ process design and automation expertise, each separator is configured to your fermentation parameters, feed characteristics and target yield. We supply, install, and integrate process automation, performance monitoring, CIP/SIP capability and real-time data logging for reliable, sanitary and scalable operation.
Key Features / Capabilities
Bioprocess-Optimised Design:
Configured for bacterial, yeast and fungal fermentation streams with high solids and variable viscosity.
Hermetic, Low-Shear Operation:
Protects fragile cells, proteins and metabolites by preventing foam, shear and oxygen ingress.
Continuous Solids Discharge:
Enables uninterrupted operation with high biomass loading and efficient recovery.
Hygienic, Sanitary Construction:
Stainless-steel wetted parts, high-polish finish, fully CIP/SIP compatible.
Automation & Process Control:
PLC-based controls for feed, discharge, cleaning and performance optimisation.
Compact & Modular Build:
Skid-mounted systems simplify integration, scale-up and service access.
Scalable from Pilot to Production:
Alfa Laval MB 20 and MB 40 series support lab through to industrial-scale capacity.
Local Service & Lifecycle Support:
Installed and supported by 4B Automation & 4B Systems, with Alfa Laval’s global service backing.
